Relative safety of first-time volunteer and replacement donors in West Africa
Identifieur interne : 000A06 ( Main/Exploration ); précédent : 000A05; suivant : 000A07Relative safety of first-time volunteer and replacement donors in West Africa
Auteurs : Jean-Pierre Allain [Royaume-Uni, Ghana] ; Francis Sarkodie ; Kwame Asenso-Mensah ; Shirley Owusu-OforiSource :
- Transfusion : (Philadelphia, PA) [ 0041-1132 ] ; 2010.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
BACKGROUND: A significantly higher level of safety between nonremunerated volunteer and replacement donor blood is assumed. This is supported by global data without stratifying between genuine replacement and paid donors, for first-time or repeat volunteer, or according to age. STUDY DESIGN AND METHODS: In 2008, first-time volunteer and replacement donors were identified, and confirmed human immunodeficiency virus antibody (anti-HIV), hepatitis B surface antigen (HBsAg), and hepatitis C virus antibody (anti-HCV)-positive screening results were collated. Data were analyzed according to age and sex between the two types of donors. RESULTS: In 6640 first-time volunteer and 4360 replacement donors, the prevalence of anti-HIV and HBsAg (1.03 and 13.8% vs. 1.1 and 14.9%, respectively) was not significantly different. Anti-HIV prevalence was higher in replacement donors less than age 20 than in first-time volunteers; the difference was not significant. HBsAg and anti-HIV confirmed-positive prevalence was significantly higher in first-time volunteer donors over age 20. CONCLUSION: In Kumasi, Ghana, viral safety of replacement and first-time volunteer donors was similar, constituting a single population of donors. Safety increment is provided by repeat donation applicable to either group, through different approaches. A blood unit from replacement donor costs half or less than that from a volunteer donor; similar studies conducted elsewhere in sub-Saharan Africa may lead to changes in current strategies.
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Relative safety of first-time volunteer and replacement donors in West Africa</title><author><name sortKey="Allain, Jean Pierre" sort="Allain, Jean Pierre" uniqKey="Allain J" first="Jean-Pierre" last="Allain">Jean-Pierre Allain</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Division of Transfusion Medicine, Department of Haematology, University of Cambridge</s1><s2>Cambridge</s2><s3>GBR</s3></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Transfusion Medicine Unit, Komfo Anokye Teaching Hospital</s1><s2>Kumasi</s2><s3>GHA</s3></inist:fA14><country>Ghana</country><wicri:noRegion>Kumasi</wicri:noRegion></affiliation></author><author><name sortKey="Sarkodie, Francis" sort="Sarkodie, Francis" uniqKey="Sarkodie F" first="Francis" last="Sarkodie">Francis Sarkodie</name></author><author><name sortKey="Asenso Mensah, Kwame" sort="Asenso Mensah, Kwame" uniqKey="Asenso Mensah K" first="Kwame" last="Asenso-Mensah">Kwame Asenso-Mensah</name></author><author><name sortKey="Owusu Ofori, Shirley" sort="Owusu Ofori, Shirley" uniqKey="Owusu Ofori S" first="Shirley" last="Owusu-Ofori">Shirley Owusu-Ofori</name></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">10-0108406</idno><date when="2010">2010</date><idno type="stanalyst">PASCAL 10-0108406 INIST</idno><idno type="RBID">Pascal:10-0108406</idno><idno type="wicri:Area/PascalFrancis/Corpus">000043</idno><idno type="wicri:Area/PascalFrancis/Curation">000090</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000030</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000030</idno><idno type="wicri:doubleKey">0041-1132:2010:Allain J:relative:safety:of</idno><idno type="wicri:Area/Main/Merge">000A15</idno><idno type="wicri:Area/Main/Curation">000A06</idno><idno type="wicri:Area/Main/Exploration">000A06</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Relative safety of first-time volunteer and replacement donors in West Africa</title><author><name sortKey="Allain, Jean Pierre" sort="Allain, Jean Pierre" uniqKey="Allain J" first="Jean-Pierre" last="Allain">Jean-Pierre Allain</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Division of Transfusion Medicine, Department of Haematology, University of Cambridge</s1><s2>Cambridge</s2><s3>GBR</s3></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Transfusion Medicine Unit, Komfo Anokye Teaching Hospital</s1><s2>Kumasi</s2><s3>GHA</s3></inist:fA14><country>Ghana</country><wicri:noRegion>Kumasi</wicri:noRegion></affiliation></author><author><name sortKey="Sarkodie, Francis" sort="Sarkodie, Francis" uniqKey="Sarkodie F" first="Francis" last="Sarkodie">Francis Sarkodie</name></author><author><name sortKey="Asenso Mensah, Kwame" sort="Asenso Mensah, Kwame" uniqKey="Asenso Mensah K" first="Kwame" last="Asenso-Mensah">Kwame Asenso-Mensah</name></author><author><name sortKey="Owusu Ofori, Shirley" sort="Owusu Ofori, Shirley" uniqKey="Owusu Ofori S" first="Shirley" last="Owusu-Ofori">Shirley Owusu-Ofori</name></author></analytic><series><title level="j" type="main">Transfusion : (Philadelphia, PA)</title><title level="j" type="abbreviated">Transfusion : (Phila., PA)</title><idno type="ISSN">0041-1132</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Transfusion : (Philadelphia, PA)</title><title level="j" type="abbreviated">Transfusion : (Phila., PA)</title><idno type="ISSN">0041-1132</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Africa</term><term>Human</term><term>Suboptimal donor</term><term>Transfusion</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Homme</term><term>Donneur limite</term><term>Afrique</term><term>Transfusion</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">BACKGROUND: A significantly higher level of safety between nonremunerated volunteer and replacement donor blood is assumed. This is supported by global data without stratifying between genuine replacement and paid donors, for first-time or repeat volunteer, or according to age. STUDY DESIGN AND METHODS: In 2008, first-time volunteer and replacement donors were identified, and confirmed human immunodeficiency virus antibody (anti-HIV), hepatitis B surface antigen (HBsAg), and hepatitis C virus antibody (anti-HCV)-positive screening results were collated. Data were analyzed according to age and sex between the two types of donors. RESULTS: In 6640 first-time volunteer and 4360 replacement donors, the prevalence of anti-HIV and HBsAg (1.03 and 13.8% vs. 1.1 and 14.9%, respectively) was not significantly different. Anti-HIV prevalence was higher in replacement donors less than age 20 than in first-time volunteers; the difference was not significant. HBsAg and anti-HIV confirmed-positive prevalence was significantly higher in first-time volunteer donors over age 20. CONCLUSION: In Kumasi, Ghana, viral safety of replacement and first-time volunteer donors was similar, constituting a single population of donors. Safety increment is provided by repeat donation applicable to either group, through different approaches. A blood unit from replacement donor costs half or less than that from a volunteer donor; similar studies conducted elsewhere in sub-Saharan Africa may lead to changes in current strategies.</div></front></TEI><affiliations><list><country><li>Ghana</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Angleterre de l'Est</li></region><settlement><li>Cambridge</li></settlement><orgName><li>Université de Cambridge</li></orgName></list><tree><noCountry><name sortKey="Asenso Mensah, Kwame" sort="Asenso Mensah, Kwame" uniqKey="Asenso Mensah K" first="Kwame" last="Asenso-Mensah">Kwame Asenso-Mensah</name><name sortKey="Owusu Ofori, Shirley" sort="Owusu Ofori, Shirley" uniqKey="Owusu Ofori S" first="Shirley" last="Owusu-Ofori">Shirley Owusu-Ofori</name><name sortKey="Sarkodie, Francis" sort="Sarkodie, Francis" uniqKey="Sarkodie F" first="Francis" last="Sarkodie">Francis Sarkodie</name></noCountry><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Allain, Jean Pierre" sort="Allain, Jean Pierre" uniqKey="Allain J" first="Jean-Pierre" last="Allain">Jean-Pierre Allain</name></region></country><country name="Ghana"><noRegion><name sortKey="Allain, Jean Pierre" sort="Allain, Jean Pierre" uniqKey="Allain J" first="Jean-Pierre" last="Allain">Jean-Pierre Allain</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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